A Message From The Founder

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A Message From The Founder

Hi I’m Tony.  I am the founder of ONE. The company was conceived shortly after my son – to give the greatest gift, a father can give his children –  personalised education from the best teachers in the world. 

When both my father and my son became ill, and we were not able to travel to each other, health took priority over education. At the time I was designing a robot to connect teachers and students with telepresence. I began to see how to apply the technology to give my family an even more important gift – personalised medicine from the best doctors in the world. 

Just as we can transport teachers to students using telepresence we can send remote medical teams to a patient. The medical industry is filled with new innovations that replace the large, expensive diagnostics machines in hospitals with tiny affordable medical devices. In December 2018 Apple released an update for iWatch to monitor ECG and irregular heart rhythm which alerts a patient of an impending heart attack. This dramatically increases the patient’s chances of survival. “Survival rate increases to 33% with response time less than 15 minutes from less than 5% with the response time more than 15 minutes.” according to a Study of Risk Factors Affecting the Survival Rate of Emergency Victims with “Chest Pain” as Chief Complaint by Biranchi N Jena and Adibabu Kadithi. 

Artificial intelligence now consistently beats doctors diagnosing a variety of illnesses. In July 2018 an AI made correct diagnoses in 87 percent of 225 cases in about 15 minutes. A team of 15 doctors from top hospitals across China achieved 66 per cent accuracy in 30 minutes. Google’s AI beats doctors at spotting eye disease in scans. An AI technique, called automated visual evaluation, found precancerous cells with 91 percent accuracy, according to a report published in the Journal of the National Cancer Institute. In comparison, a human expert review found 69 percent of precancerous cells, while conventional lab tests like Pap smears found 71 percent.

Artificial intelligence is smashing almost every industry into pieces.  For education, AI opens profound insight into students. It can connect students with personalised content, tailored to their desires, abilities and needs. AI builds on its knowledge of the student and optimises teaching in real time as it learns. It can continuously assess learners who can earn credits and certification based on their knowledge and skills. This empowers AI to sequence the right learning activities, to the right student at the right time. The more AI knows about a student the better it can teach her. It can connect students with other students with similar interests. It can connect students to the right teachers, acquire knowledge and earn credits, points, tokens and certificates. AI can classify, connect and assess content, learning activities and people. It can create learning activities, new knowledge and theories. Our goal is to create your own personalised AI that will continuously learn about and extend each student’s knowledge. It will actively acquire and connect you with the right content, learning activities, students, teachers, schools, employers and intelligence.  

For healthcare AI opens a profound insight into patients. It can connect patients with personalised treatment plans, tailored to their symptoms, age, sex, environment and DNA. AI builds on its knowledge of the patient and optimises therapy in real time as it learns. It can continuously assess patients vital signs while having a complete understanding of a patient’s characteristics and medical history. This empowers AI to sequence the right medication, at the right dose, to the right patient, at the right time. The more AI knows about a patient the better it can care for her. It can connect patients with other patients with similar conditions. It can connect patients to the right doctors, classify and assess symptoms, diseases and therapies. In many cases, it can diagnose illness and prescribe the right medication more accurately than humans. AI can be used to create new drugs and therapies using code from your DNA. Our goal to create your own personalised AI that will continuously learn about, protect and grow each patient’s  health. It will actively assess and connect you with the right therapies, physicians, hospitals, labs and intelligence.  

For marketing, AI opens a profound insight into customers. It will continue to become exponentially more powerful and dangerous as it integrates with humans on a molecular level. The speed that this is happening is astounding. The cost of DNA sequencing has plummeted from $100 million (2001) to $10 millon (2005) to $1 millon (2006) to $1,000 (2018) to FREE (if you share your personal information and saliva) today. 

In July 2018 my father’s genotype was rented to Galixo Smith Klien by 23andme. GSK paid US$300 million for 4 years access to 23andme’s database of 5 million customers so they could develop new drugs. I had sequenced a small part of my father’s DNA with 23andme when they launched first – before they removed their health products and masqueraded as an ancestry company.  

I understood that 23andme were primarily in health care but they were restricted by what they can do by the FDA. I didn’t feel lied to like many of their customers when they learned about what was happening to their DNA. 23andme’s strategy to acquire so much DNA was brilliant. But they didn’t reward my Dad for sharing his DNA and I’m concerned about his privacy. Even if you remove personal information from DNA it will become easier and easier to match an individual to “anonymous” DNA. For example, Raymond Charles Rowe, known as DJ Freez, was convicted of murder after he was identified as a suspect from DNA that a relative had submitted to a genealogy database.

I opted my Dad out of 23andme’s sharing with GSK and others. Then I downloaded his genotype and used it to assess his genetic health risks, and more importantly, to predict his response to prescription drugs. My Dad’s DNA predicted he would get his illness. If my children and I carry the same code I can use this information to try prevent the disease. To help my Dad, however, I needed to look at drug-gene interaction. 

In the US the FDA requires pharmaceutical companies to print pharmacogenomic guidelines on their labels. However, most DNA sequencing companies are restricted by the FDA to provide analysis for your health. The restrictions do not apply to individual patients. I took his raw DNA data and analysed it against several drug gene interaction databases. I found that he may have an abnormal sensitivity to 71 different drugs. I identified that his current medication may pose risks for his genotype including increased risk for adverse cardiovascular events. I found that The Clinical Pharmacogenetics Implementation Consortium recommended therapy if no contraindication, for his genotype. 

Adverse drug reactions are the fourth commonest cause of death in the US after heart disease (nearly 750000 deaths), cancer (530000), and stroke (150000) according to Journal of the American Medical Association. “There are an estimated 100,000 deaths and more than two million serious adverse reactions attributable to prescription drug use in the United States each year, at a cost to the healthcare industry that exceeds $136 billion annually.” Without prior knowledge of an individual patient’s genetic profile physicians prescribe drugs in a trial-and-error manner which results in unnecessary cost and deaths.

There is no doubt that precision medicine can have a huge impact on your life expectancy. It protects your health by detecting diseases early, or even prevents them from developing. Precision medicine arms your physician with the essential knowledge needed to diagnose illness and predict adverse drug reactions. Precision medicine empowers your doctor to predict your likely response to certain medications and to prescribe the right drugs, at the right time, in the right dose. This same technology can be used to target the right knowledge to learners and messages to customers. 

Precision medicine is personalised medicine. While the FDA requires pharmaceutical companies to analyse drug gene interaction it does not place this requirement on patients. To take advantage of the profound impact that precision medicine can have on your health patients must take control of their own healthcare. ONE provides you with the opportunity to step ahead of the limitations of the current healthcare system with your own intelligent machine whose goal is to protect and extend your life. 

ONE provides you with the opportunity to step ahead of the limitations of the current education system with your own intelligent machine to acquire and sequence learning based on your personal knowledge, skills and needs. 

ONE provides your company with the opportunity to step ahead of the limitations of current marketing with an intelligent machine that will acquire, convert and grow customers using the conversational web. 

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